Is it possible to do a self-drive tour of Patagonia?

We'd like to combine our Antarctic cruise with an overland trip to Patagonia. Considering a small group tour but none match up with our dates. Is it possible to self drive, either starting in Ushuaia and finishing in Santiago or vice versa, or can an operator make an itinerary for us? V. Copping, Oatley NSW

​Since Ushuaia and Santiago belong to two different countries you can't hire a vehicle to travel between them. You could fly between Ushuaia to Punta Arenas, or take a rather long bus ride, and either pick up or drop off your hire car there but as far as I can tell the one-way drop-off fee for driving between here and Santiago is steep.

Argentina's Say Hueque is one operator you could try and their reviews are good. Another is Sydney-based World Expeditions. They have a long history of South American operations and you could create your own adventure with one of their custom-made itineraries.Chimu Adventures is another Australia-based operator with deep expertise in this region that also can tailor-make an itinerary just for you.