Wine buffs short on time can learn about and taste Chile's vineyard varieties in downtown Santiago.
The Peruvian city of Cusco is home to half a million residents but attracts four times as many visitors each year.
Marine iguanas forage for algae on a bed of volcanic rocks, sea lions corkscrew playfully through the water - snorkelling in the Galapagos Islands is just like being in a nature documentary.
It's not a country. It's not in one country, either, shared as it is by Chile and Argentina.
Rich cultural influences, astounding local produce and top-drawer chefs are bringing Peruvian cuisine to the world.
Cuzco's historical heart is a great place to spend an afternoon people-watching while you acclimatise to the city's 3300-metre altitude.
One notable Buenos Aires building is both a people's favourite and, paradoxically, was voted the city's ugliest building.
Tango, shop and eat and your way around this cosmopolitan South American city that feels a little bit European.