Six years after axing the Brisbane to Bali route in the wake of a fatal plane crash, Garuda Indonesia is reintroducing the service.
From August the airline will fly daily from Brisbane to Denpasar.
The move has been welcomed by Queensland Treasurer Tim Nicholls and Tourism Minister Jann Stuckey, who said it would enhance trade relations between Indonesia and Queensland.
"These flights will bolster ties between our two regions, increasing Queensland's connection with Indonesia," Mr Nicholls said.
"Last financial year, Indonesia was Queensland's ninth largest merchandise export destination, worth almost $1.2 billion to the state's economy.
"This figure has more than doubled in the last ten years.
"The announcement of these flights gives a clear indication of Indonesia's continued confidence in our economy."
Garuda Indonesia has spent years rebuilding its reputation in the wake of a domestic Boeing 737 crash at Yogyakarta Airport which killed 21 people, including five Australians.
The new flights will depart daily from Brisbane to Denpasar on Garuda Indonesia's B737-800 next generation aircraft, which can seat 162 passengers.